Order 4-AcO-DMT Online (or psilocybin) can described as a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolised by the body into psilocin.
Most people buy psilocybin as a brown or off-white powder that can be mixed with water just before dosing. But it’s also available in pills, tablets, capsules, and gel tabs among other preparations.
While some find the effects indistinguishable from psilocybin mushrooms, others say it’s more like DMT. The difference may be dose-dependent. But mystical-type experiences are common, as are philosophical insights and a sense of empathic well-being.
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4-AcO-DMT may be useful for clinical research. Researchers used it to test the hypothesis that 5-HT2A agonists can alleviate withdrawal symptoms. They also explored whether these agonists could prevent the formation of addictions.
Opiate-dependent rodents given 4-AcO-DMT were effectively cured of their addiction. A single dose of 4-AcO-DMT given prior to chronic nicotine exposure blocked their transition to a nicotine-dependent state.
How 4-AcO-DMT may be used to treat addiction in humans remains to be seen, but these results support neurobiological theories of dependence—and in particular, the hypothesis that serotonergic agents can be used to regulate underlying mechanisms involving GABA (gamma-aminobutyric acid) receptors and BDNF (brain-derived neurotrophic factor) in the ventral tegmental area of the brain
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